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It is unknown whether circulating NE influences mitochondrial melatonin synthesis in peripheral organs since melatonin is not usually released from these cells and as a result it would not be reflected in blood melatonin concentrations

These findings suggest that the mTOR pathway plays a key role in peripheral sensitization

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Furthermore, the somatic mutation of PIGR in the colon has been considered as one of the causal roles in the pathogenesis of IBD in patients (Olafsson et al., 2020)

"Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors"