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Among these, random mutagenesis techniques such as ultraviolet (UV) irradiation effectively generate phenotypic diversity without using recombinant DNA technology (Jeyachandran et al., 2024)

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The diagnosis usually involves the following: clinical findings, the finding of 5-oxoprolinuria, low levels of glutathione, low activity of glutathione synthetase, and mutation analysis of the glutathione synthetase gene