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Description

Hernandez-Olivan P

Author contributions SAC: Writing review & editing, Conceptualization, Validation, Writing original draft, Supervision, Data curation

Due to the continuous exposure to occlusal forces and periodontal microorganisms, alveolar bone possesses a unique immune microenvironment distinct from the long bones, with more frequent interactions between monocytes/macrophages and MSCs (Sima et al., 2019)

Experimental study demonstrates that LDN induces a phenotypic shift in BV-2 microglial cells, transitioning them from a pro-inflammatory(iNOS high CD206 low ) to a quiescent, anti-inflammatory M2 state (iNOS low CD206 high ) [150]