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Description

The model suggests that this decrease is caused by the sequestration of Keap1 in the complex with Nrf2 due to its interaction with DEM

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Uncontrolled production of ROS and cytokines results in oxidative stress and inflammation

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GSSG sensitized hepatocytes to TNF-mediated cytotoxicity via the induction of IKK- glutathionylation and subsequent NF-B suppression NF-B activation plays a critical role in protecting hepatocytes from TNF-mediated cytotoxicity

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Carlson MDA, Morrison RS (2009) Study design, precision, and validity in observational studies

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DAG remains membrane-bound and promotes protein kinase C (PKC) activation, whereas IP diffuses into the cytoplasm and binds IP receptors (IPRs) on the endoplasmic reticulum (ER), triggering Ca release 25

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