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pmc.ncbi.nlm.nih.gov

Notably, emerging evidence reveals that HIF-1 transcriptionally activates heat shock factor 1 (HSF1), the master regulator of the heat shock response [56, 57]

This was investigated further, and, when faced with a low-glucose/low-glutamine environment, these cells were shown to rely on fatty acid oxidation or acetate for energy to mount a cytokine response, further highlighting the metabolic resilience of NK cells