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Moreover, this effect is most pronounced in the oldest flies (30 days old at time of APAP administration) and is observed in both males and females (Fig

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Upon IGF-I binding, the -subunits undergo conformational change which causes activation of the internal kinase activity and autophosphorylation of the kinase domain which then phosphorylates insulin receptor substrate-1 (IRS-1)[81]

Whereas for KA it takes some time and energy to go from the peripheral docking site to the inner active site, for HQ there is constant interconversion between the two of them suggesting that the pre-docking site is very transient