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Similar content being viewed by others Introduction Obesity is a chronic disease characterised by excess adiposity that impairs health and affects about 650 million people worldwide [1, 2]

Notably, senescent renal TECs may induce fibroblast activation and proliferation by releasing Sonic hedgehog protein, contributing to the progression of DKD (13)

Research has explored the effects of exogenous MOTS-c exercise protocols, revealing significant improvements in physical capacity

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There are multiple ongoing phase III studies to investigate survodutide for treatment of obesity, diabetes, cardiovascular disease, and chronic kidney disease