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Pegloticase immunogenicity: The relationship between efficacy and antibody development in patients treated for refractory chronic gout

bioRxiv Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

IR and T2DM, as core components of endocrine dysfunction, play a central role in the development and progression of MASLD, representing a broad area for ongoing research into novel therapeutic approaches [61]

10.1074/jbc.REV119.006217 98 HeX.-f.LiuD.-x.ZhangQ.LiangF.-y.DaiG.-y.ZengJ.-s.et al (2017)

Once toll-like receptor 4 (TLR-4) is activated, Tir domain-containing adaptor inducing interferon-beta (TRIF) can bind to TRAF6, then activate a series of kinases, promote entry of activated nuclear factor-kappa B (NF-B) into nucleus and activate the transcription factor, ultimately leading to the expression and release of inflammatory cytokines