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Reduced use of cholesterol and sphingomyelins is sufficient to promote synapse formation As ncr-2(0) mutants exhibited higher levels of cholesterol and sphingomyelin in comparison with WT, we next explored whether the synaptic phenotypes observed in ncr-2(0) mutants were attributable to the elevated cholesterol and sphingomyelin levels

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Abnormalities in skin sympathetic responses and thermoregulatory sweat tests have also been reported

Studies have demonstrated the role of vitamin C in skin inflammation [89]