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W.BodhinathanK.TsaiE.MarshN.et al (2017)

Although, strictly speaking, a sodium concentration outside the range of 135-145 mmol/L denotes dysnatremia, clinically relevant hypo- or hypernatremia is mostly defined as a sodium concentration outside the extended normal range of 130-150 mmol/L [59]

Preclinical research examining cellular adaptation and response to experimentally induced stress or injury

The evidence tier that is fully published and verifiable is Phase 2

Drugs used to prevent migraines include blood pressure medications (e.g., beta blockers, calcium channel blockers, ACE inhibitors, and angiotensin receptor blockers), tricyclic antidepressants (e.g., amitriptyline [Elavil]), and anticonvulsants (e.g., valproate [Depakote], gabapentin [Neurontin], and topiramate [Topamax])