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Statements Author contributions ASk: Conceptualization, Data curation, Supervision, Visualization, Writing original draft, Writing review & editing

The problem arises when too much homocysteine is available, and it ends up being incorporated into too many proteins

Br J Pharmacol 119(8):15331540 Mehta R, Pascual M, Soroko S, Savage B, Himmelfarb J, Ikizler T, Paganini E, Chertow G (2004) Spectrum of acute renal failure in the intensive care unit: the PICARD experience

Across chemotherapy, targeted therapy and immunotherapy, primary and acquired resistance and subsequent relapse remain common

Our roGFP2 measurements confirm (i) that dynamic roGFP2 sensing (or the physiological glutathionylation/deglutathionylation of regular surface-exposed cysteinyl residues) requires a glutaredoxin activity, and (ii) that glutathionylated proteins or metabolites should be very transient redox species when GSH and glutaredoxins are present (unless they are stabilized by a kinetic uncoupling mechanism) 5,32,34,35,61,62,63,64