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However, mRNA levels of neurotrophic factors, including IGF-I, GDNF, BDNF, and anti-inflammatory factors were decreased in the spinal cords of SOD1 G93A /RAG2 / and SOD1 G93A /CD4 / mice, as were the levels of CX3CR1 and several glutamate receptors

MMPs, the collagen-degrading enzymes secreted by keratinocytes and fibroblasts, promote collagen breakdown and decrease collagen synthesis 2

Several other studies (one of them being a large scale community-based Framingham Heart Study [221]) have suggested a role for IGF-1 in the prevalence of insulin resistance and MetS [221223]

Glutathione is a potent antioxidant, one that naturally exists within the body but decreases with ageing, poor dietary habits, pollution, and stress

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