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Figure 1 Cytochrome P450-Mediated Metabolic Activation APAP metabolic activation is mainly catalyzed by the cytochrome P450 enzyme and the reactive metabolite associated with hepatotoxicity is commonly considered to be NAPQI (Streeter et al., 1984)

After three months of treatment, 77% of patients reported significant improvement in pain scores and autonomic symptoms

Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension

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