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wherein L236 is substituted with either an A, C, D, E, F, G, H, I, K, M, N, P, Q, R, S, T, V, W, or Y

Mechanistically, it was found that P53 can inhibit ferroptosis in hepatocellular carcinoma cells by promoting the entry of DPP4 into the nucleus and forming a DPP4-P53 complex

doi: 10.1016/S1388-1981(00)00044-5

30,31 Additionally, reporting MCID thresholds in addition to CFB across measures allows patient-level responses to be considered alongside the average improvement in the study population, which is important given some patients may not respond to treatment