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Regulation of the PPP Earlier studies reported a regulatory influence of carbon sources and nitrogen sources on the PPP and linked this to the NADPH production by the PPP

In addition, other signs of astrocyte activation during senescence include cellular hypertrophy with increased cytoplasmic organelles and glial filaments, reduction in the number of astrocytes, expression of proinflammatory cytokines such as IL-1, IL-6, TNF-, and IL-1 and ROS generation (Nichols et al., 1993