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ART is primarily administered orally, characterized by rapid onset of action but suffers from a short in vivo half-life (approximately 1 h) ( Dimeric artesunate phospholipid-conjugated liposomes (Di-ART-GPC), a novel derivative synthesized through the esterification of artesunate and choline glycerophosphate, exhibits low cytotoxicity with enhanced anti-inflammatory and antimalarial effects compared to ART alone ( In vitro drug release and degradation results showed that the Di-ART-GPC were stable in neutral physiological conditions but effectively degraded to release parent ART in the simulated weakly acidic microenvironment

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So basically there's a lasting effect of feeling good

Mice were allowed to acclimatise for at least 1 week prior to the experiment

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