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Data collected from immunohistochemical staining revealed that significant up-regulation of BAX expression as well as remarkable down-regulation of Bcl-2 staining were observed in hepatic tissues following CSD (Figures 6B,E,M,N)

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However, the basis for the increased lactate and pyruvate, in some instances, may relate to non-mitochondrial processes such as glycolysis as is suggested by the absence of increased alanine and TCA intermediates noted in some other biomarker clusters (Figure 5, group 4)

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