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Peroxynitrite is documented to be highly injurious, and its reduction yields neuroprotection following experimental TBI and ischemia reperfusion (IR) injury [35, 4042]

Neovascularization involves several growth factors and cytokines, such as fibroblast growth factor (FGF), platelet-derived endothelial cell growth factor (PD-ECGF), angiopoietin (Ang)1/2, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), among which vascular endothelial growth factor (VEGF) is the most vital irritant

Wu Y, Lyu H, Liu H, Shi X, Song Y, Liu B

These proteins can increase the risk of thromboses (blood clots)

Biallelic lossoffunction mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humans