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doi: 10.1016/j.expneurol.2024.115084, 124 WilliamsonT

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In addition, some of the environmental ALS risk factors, including exposure to agricultural chemicals, heavy metals, excessive physical exertion, chronic head trauma, and smoking, have been associated with oxidative stress, suggesting that the development of ALS can be facilitated by any factor that favors a prooxidative state[51]