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Apoptosis To detect apoptotic nuclei, TUNEL staining was performed using an ApopTag Red In situ Apoptosis Detection Kit (Millipore, S7165, Darmstadt, Germany) according to the manufacturers instructions

The combination has not shown any emergent toxicity beyond what would be expected from either peptide individually

696 Compared with normal tumors, tumors harboring SDH mutations typically exhibit increased aggressiveness and a significantly faster proliferation rate