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3 The metabolic plasticity in this context poses challenges for cancer therapies targeting the Warburg effect, as complete blockade of glucose uptake often proves to be unfeasible

This System Xc /GSHGPX4 axis is thus a major ferroptosis pathway, with direct relevance to renal I/R injury

Of note was the large (8- to 13-fold) increase in the conversion of E1 into its hydroxylated and methylated forms compared to the 2- to 5-fold increase observed for most other metabolite ratios

With a similar oxygen affinity to myoglobin ( P 5 0 = 110 mmHg), in vivo experiments indicate its role in protecting the brain and nervous system from hypoxia and oxidative stress 68

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