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Unlike FDA-approved drugs, compounded medications are not individually evaluated by the FDA for safety, effectiveness, or quality before being dispensed

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When metabolic stress occurs, MOTS-c in cells can be transferred to the nucleus in an AMPK-dependent manner and bind to transcription factors regulated by ARE, thus improving the stress resistance of cells (16, 24)

By employing a combination of spectrometric, biochemical, and morphological approaches, this study clearly demonstrated that ALA effectively stabilizes hepatic Fe 2+ expression (Figure 1), alleviates ferroptotic changes (Figure 2), reduces oxidative stress by enhancing phosphorylated Nrf-2 activation-mediated downstream anti-oxidative enzymes expressions (Figure 3), decreases the production of NF-B-mediated inflammatory factors (Figure 4), depresses the activation of ER stress signaling (Figure 5), as well as counteracts the imbalance of pro- and anti-apoptotic proteins following CSD (Figure 6)