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In addition, E3 ligases anaphase-promoting complex subunit 2 (ANAPC2) promotes KRAS degradation through the ubiquitinproteasome pathway in colorectal cancer [179]

ECHA (2017) Read-across assessment framework (RAAF)

However, when it is taken in more significant quantities than recommended or without a prescription, it can lead to serious consequences

10.1016/j.redox.2015.06.020 188 VermaA

It is an alteration in the balance of prooxidant /antioxidant system in favour of prooxidant with attendant lethal effects with resultant damage to the cellular macromolecules (Fig