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The patient then began ATO (0.16mgkg -1 d -1 ) intravenous chemotherapy combined with oral ATRA (25mgm -2 d -1 ), continuing with the first treatment course for induction therapy

Takai, S., Jin, D., Sakaguchi, M

These were generally mild, in the range of 2-4 beats per minute at lower doses and up to 6-8 BPM at 12mg, and did not produce clinical symptoms in most participants