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found that 56 of the top 100 best-selling drugs in the United States target products of a circadian gene 24

In mammalian cells, DNA double-strand breaks are primarily repaired through NHEJ, an error-prone pathway that generates unpredictable insertions or deletions, rather than through the desired HDR pathway [238]

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Moreover, Dysbiosis can trigger an inflammatory response, characterized by the release of pro-inflammatory cytokines such as TNF- , IL-6, and IFN- , these cytokines can directly affect the expression and distribution of TJ proteins (38)