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A landmark randomized, double-blind, placebo-controlled trial published in Obstetrics and Gynecology found that vitamin B6 at 25 mg every eight hours significantly reduced nausea severity compared to placebo

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Furthermore, the cholesterol-metabolizing enzyme cholesterol 25-hydroxylase (CH25H) and its product, 25-hydroxycholesterol, regulate activating transcription factor 3 (ATF3) expression to promote tight junction protein production and protect the intestinal barrier [390]