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3.4 Immune-function activity Various species of mushrooms, particularly Pleurotus ostreatus and their lectin extracts, can enhance the activity of the defensive system in humans, as demonstrated in in vitro and in vivo studies (19)

Another small clinical trial, comprising six patients with GBM who underwent multiple cycles of BBB disruption using MRgFUS to enhance the penetration of TMZ chemotherapy, also found that MRgFUS is safe and well-tolerated without any significant long-term complications at 1-year follow-up [119]

doi: 10.1007/978-3-319-18881-2_2 51 EstevesSCSnchez-MartnFSnchez-MartnPSchneiderDTGoslvezJ

Alcohol and cancer: Mechanisms and therapies