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Since the low concentrations of cobalamin in our subjects were found as part of a screening program, in the absence of specific clinical symptoms, we assume that the subjects were at an early stage of negative cobalamin balance [16]

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[7] (This interaction is not significant when levodopa is combined with carbidopa, as in standard carbidopa/levodopa therapy, because carbidopa prevents peripheral levodopa breakdown.) Another notable interaction involves the chemotherapeutic agent altretamine: coadministration of pyridoxine can decrease altretamines effectiveness and is generally advised against unless specifically directed

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