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doi: 10.1056/NEJMoa1511410 41 Den BoonSMarstonBJNyenswahTGJambaiABarryMKeitaSet al

Murine tumor necrosis factor alpha is transported from blood to brain in the mouse

Interstitial delivery Drug delivery through intrathecal and intracerebroventricular strategies elude the BBB to some point, the direct administration of therapeutic drugs into the interstitium is the most direct strategy of brain targeting delivery systems [168]