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Since the introduction of kava consumption to Western society, other solvents have been used to optimize the kavalactone extraction yield, often resulting in higher concentration of these active compounds, but also other potentially less desirable (even dangerous, see later discussion) flavokavains and alkaloids [15,32,35,38,40,41]

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PCA analysis in both positive and negative ion modes demonstrated that the metabolic profiles of the fecal matter differed among the experimental groups (Fig

Microglia in the developing brain are also sensitive to external perturbations such as maternal infections (Smolders et al., 2015