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The citation is: Hannah Wilson, Caroline Wieler, Darci Bell, Ajit Bhattarai, Isaura Castillo-Hernandez, Ewan Williams, Ellen Evans, Alison Berg

Second, we integrate recent molecular evidence spanning both classical and emerging pathways in lipid metabolism (including AMPK, SIRT1, PPAR, and PGC1) as well as metabolicinflammatory signaling related to insulin resistance (e.g., activation of IGF-1/AKT and inhibition of NF-B)

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later found that Ambroxol and NAC (200 mg TID) prevented FEV 1 decline over 12 weeks, unlike placebo (103)