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Ma QL, Zhu C, Morselli M (2020) The novel omega-6 fatty acid docosapentaenoic acid positively modulates brain innate immune response for resolving neuroinflammation at early and late stages of humanized APOE-based Alzheimers disease models

Thus, we have only just begun to investigate the effects of sleep deprivation on the epigenome, leaving many exciting areas left to explore

Moreover, in models of ischemiareperfusion injury and in KEAP1-inactivated lung cancer, inhibition or genetic ablation of CoQ biosynthetic enzymes restored sensitivity to ferroptosis or radiotherapy 115,116 , underscoring the reliance of some cancer cells on an abundant CoQ pool for redox defense and survival

Benefits have also been shown in low back pain, autistic spectrum disorders and aphthous ulcers, although this is based on small numbers of clinical trials

Our results extend this understanding by showing that conjugated primary and secondary BAs are associated with mental health outcomes