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Am J Physiol Heart Circ Physiol 325:H398H413

As cellular GSH is depleted, first individual cells die in those areas most affected

Drugs with a Vd value of less than 0.3 L/kg are predominantly confined to the ECF, whereas drugs with a Vd value of greater than 1 L/kg are highly lipid soluble and tend to distribute out of the extracellular fluid and into tissue compartments (Box 4-1)