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Depending on the relative loss of water and solutes from extracellular fluids, dehydration can be hypertonic (water loss concentrates extracellular water), hypotonic (sodium loss dilutes extracellular water) or isotonic (water and sodium losses with no change in concentration)

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Somoza-Moncada MM, Turrubiates-Hernndez FJ, Muoz-Valle JF, et al

For instance, hereditary folate malabsorption, caused by mutations in the Proton-coupled folate transporter (PCFT )gene (SLC46A1), impairs folate transport in the intestine and brain, leading to systemic folate deficiency with symptoms such as megaloblastic anemia and neurological impairments, including developmental delays and seizures [30]

This trial recruited patients with a history of migraine headaches with or without aura occurring on average twice or more a month for the preceding three months