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Within the white matter, 22% of lesions were found to be shadow plaques, 73% were partially remyelinated, and only 5% were completely demyelinated (Patani et al., 2007)

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However, total alpha-synuclein in the CSF, does not show a consistent relationship with Lewy body pathology, or change over time in relation to motor or cognitive measures 8,9 , and quantification metrics of the alpha-synuclein SAA are not yet validated or robust across different laboratories

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