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(Study: Frias et al., 2021) Dual Agonism: Tirzepatide's distinctive dual mechanism of action combines GLP-1 receptor activation with glucagon receptor activation, potentially resulting in even more pronounced weight loss compared to traditional GLP-1 RAs

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[5] Notably, the only observable mass-modifying implications of Frag 176-191 were observed only in obese murine models, with no changes observed in lean research models within the same study