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-heguelin is a monodesmotic triterpenoid saponin isolated from Hedera nepalensis K.Koch [236], which induces apoptosis at high doses, disrupts the redox system by significantly affecting glutathione metabolism at safe and low toxic doses to induce ferroptosis in NSCLC, and also increases the sensitivity of NSCLC cells to cisplatin [237]

Second, ferroptosis-modulating tools with precise spatial and temporal control should be developed, such as nanodelivery systems activated by local microenvironmental features (e.g., pH, reactive oxygen species), to avoid off-target toxicity in healthy neural tissue

Myeloblastin gene expression in normal hematopoietic subpopulations and leukemias