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Because MOTS-c is naturally produced in response to exercise, and because it activates the same AMPK and mitochondrial biogenesis pathways that exercise training upregulates, combining exogenous MOTS-c with a structured exercise program creates a reinforcing signal that operates through the same biological channels

Hence, pharmaceuticals that target the NRF2 pathway can influence multiple pathways involved in the neurodegenerative process, and therefore hold potential to become therapies that can significantly modify the course of neurodegenerative diseases

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A gradual increase on to activity of GT was reported with the increasing on the reaction temperature, till maximum activity at 3742 C followed by a dramatic decrease on its activity at 6070 C (Fig