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Description

Cell lines and isolated cells Human iPSC-derived ventricular cardiomyocytes (Ax 2505) were obtained from Axol Bioscience, UK, human cardiomyocytes (HCM) from two different donors (C-12810) and HCF (C-12375) from PromoCell, Germany, and mouse embryonic fibroblasts (MEFs: wild-type SV40, ATCC-CRL-2907

Very frequent dosing (e.g., every 2 hours) can cause progressive attenuation due to acute tachyphylaxis [3]

Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice