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Pharmacological therapies that facilitate ATP-dependent futile cycles and/or reduce the efficiency of ATP synthesis may thus exert more toxic effects on breast cancers with broad metastatic potential and high energy demand such as MDA-MB-231 cells

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However, the PDMS block was fabricated to minimize its footprint, implants were retrieved cleanly after animal sacrifice, and measurements were made in regions where the epineurium appeared intact (even if thickened), suggesting that such impacts were unlikely to be substantial