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TMAO was shown as widely distributed in sea animals [74], with concentration in the tissue increasing proportionally to the depth of the fishes natural environment [75]

Chen, N

A double-blind, placebo-controlled trial in 90 HIV-positive patients with symptomatic distal symmetrical polyneuropathy found no benefit of intramuscular injection with 1 g/day of ALCAR for two weeks in the intention-to-treat analysis, but there was some pain relief in the group of 66 patients who completed the trial (84)

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Migraine in mitochondrial disorders: prevalence and characteristics