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Unlike orthosteric agonists, 52 did not cause receptor desensitization even with repeated dosing, and is currently being evaluated in clinical trials for its efficacy and safety in mild to moderate AD patients

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As a pro-oxidant, Cu can participate in Fenton-like reactions, producing highly reactive hydroxyl radicals from hydrogen peroxide

Moreover, our results highlight the essential role of vitamin B12 in homocysteine metabolism, as supplementation was associated with a significant reduction in serum homocysteine levelsan important biomarker associated with cardiovascular and neurodegenerative diseases

Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype