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This section highlights key examples of TCM-derived metabolites that have made significant strides toward clinical translation, including berberine, quercetin, and the polyherbal Qili Qiangxin capsule, focusing on trial data, outcomes, and safety profiles ( 3.1 Clinical evidence and translational successes As a single-metabolite supplement, berberine has been used in East Asia for metabolic and cardiovascular health for decades, and Western interest has increased in recent years (Song et al., 2020)

Shah A, Kumar S, Simon SD, Singh DP, Kumar A

However, in the treatment of peptic ulcers, the combined use of antibacterial synthetic drugs such as amoxicillin and metronidazole (AMPC - MET) significantly reduces the bioavailability of PF in SGD and significantly decreases the AUC of GA

In one approach, Dutta et al

[DOI] [PubMed] [Google Scholar] Makino Y, Sakagami H, Takeda M