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As the mitochondria fail, the patient experiences a catastrophic drop in available cellular energy, making even minor physical or cognitive tasks feel impossible

The subchondral bone was categorized into damaged area (OA sample) and corresponding undamaged area (control sample)

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To elucidate the relevance of charge and size of the side chain of the scaffold candidate, we replaced Glu170 of ScGrx7 with Asp, Ala or Lys

Since then, multiple RCD patterns have been identified (Fig