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doi: 10.1002/brb3.1726

2013;68(5):693e1

Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

Les radicaux libres sont des substances formes dans le mtabolisme qui peuvent tre potentiellement toxiques

However, mutant variants such as A53T bind to the lysosomal receptor LAMP2A but fail to translocate into the lumen, resulting in a blockage that impairs not only their own degradation but also that of other CMA substrates [171, 172]