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Specifically, the Mediterranean diet (MedDiet) has gained attention for its potential benefits in DM prevention (13)

The compound then received GRAS (Generally Recognized as Safe) designation from the FDA for use as a food ingredient, which is a separate regulatory category from drug approval

Nevertheless, it was only relatively recently when the group of Dean Jones defining the cellular redox environment by estimation of the ratio of glutathione/glutathione disulfide couple concluded that each phase in the life of the cell is characterized by a particular redox state and that proliferating cells are in a most reduced state [11]

Beutler et al., 1995)

Such a redox imbalance, apparently, leads to an increase in the amount of oxidized forms of low-molecular-weight thiols in cells and, as a result, to a depression (decrease in efficiency) of protective mechanisms involving thiols