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Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo

It is well known that patients with AD have a progressive deposition of amyloid- (A) plaques and neurofibrillary tangles in the brain

In contrast, an arrestin is involved in hDOR internalization but not desensitization upon DPDPE (Aguila et al., 2003b) while upon DPDPE exposure, the receptor is mainly targeted to lysosomes for degradation (Marie et al., 2003b) probably by a mechanism involving GASP (Whistler et al., 2002)