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Complex IV, Cytochrome c oxidase

(92) conducted a 16-week randomized, double-blind, controlled trial with 196 patients, finding that omega-3 PUFAs significantly reduced the total number of migraine attacks compared to placebo, though a strong placebo effect was observed, and the study did not confirm earlier findings from smaller studies

Brain-derived Neurotrophic factor ( BDNF ) is essential for neurogenesis and extensively studied as a biomarker in psychiatry (Lin & Huang, Reference Lin and Huang2020) There is extensive evidence of a difference in DNAm in BDN F, as well as EWAS studies showing enrichment for the neurogenesis pathway in SCZ (Di Carlo et al., Reference Di Carlo, Punzi and Ursini2019

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Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process