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If DMSO was used to solubilize the drug(s), three wells with the highest relevant concentration of DMSO were included in the plate as a negative control

Selenium, Se

Importantly, the cells response to injury can also vary in accordance with the level of stress (low versus high) and the length of exposure (acute versus chronic), such that young healthy cells may counter acute stress more formidably that aged cells, specifically effecting cellular processes including autophagy, phagocytosis, proteosomal degradation, toxic clearance and metabolism, among others

identified PDLCs, which highly express SLC7A11 and GPX4, as critical targets of compromised antioxidant defense

Glycine also contributes to the production of glutathione, a powerful antioxidant, and creatine, which supplies energy to muscles