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Overall, the biological processes in the human liver where proteins of the human HPX interactome are involved include regulation of lipid metabolism (regulation of lipase activity, cholesterol homeostasis), receptor-mediated endocytosis, immune system activation (complement activation, antibacterial humoral response, defense response to bacterium), and regulation of coagulation and wound healing

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Previous studies have demonstrated that Nrf2 plays a crucial role in responding to antioxidative stress and maintaining redox homeostasis

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Ruhoy and Saneto, 2014